Nanotechnology Platform Could Improve Stem Cell Transplantation?





Stem cells can grow into many non-identical kinds of cells, including neurons that transmit information within the brain. Adult human-induced pluripotent stem cells, which resemble embryonic stem cells, are often used to develop drugs and model diseases. While stem cells hold great potential for treating neurodegenerative diseases and central nervous system injuries, controlling and characterizing their fate are critical issues that need to be addressed before their potential use as treatments is often fully realized. Current methods for characterizing stem cell biomarkers destroy cellular activities and functions, which makes it difficult to conduct more definitive research that might cause biomedical applications.

Using their nanotechnology platform, the scientists successfully monitored the generation of neurons from human stem cells by characterizing next-generation biomarkers called exosomes—tiny particles released by cells that play a critical role in cell-to-cell communication. The scientists will further investigate their technology's versatility in other applications, like detecting neurons in clinical settings.

The nanotechnology platform, which uses special tiny rods for sensing, allows researchers to verify the identity of human stem cell fates and their biomarkers, or biological molecules, without destroying them, according to a study within the journal ACS Nano. That's been a significant issue during pre-clinical research on stem cells because it limits further analyses and biomedical applications. "One of the most hurdles within the present cell-based therapies is that the destructive nature of the standard cell characterization step. With our technology, we'll sensitively and accurately characterize the cells without compromising their viabilities,"

Controlling and characterizing stem cells could also be a critical issue to affect before transplantation medicine is often fully developed. Current methods destroy cellular activities and functions, making it difficult to conduct more definitive research that might cause biomedical applications.

The new nanotechnology the researchers developed could also be a multifunctional magneto-plasmonic nanorod (NR)-based detection platform. The team was able to successfully monitor the generation of neurons from human stem cells by characterizing next-generation biomarkers called exosomes. These cells play a critical role in cellular communication. The authors said their “multifunctional magneto-plasmonic NR-based exosomal miRNA detection platform features an excellent potential to research the function of cell-cell interactions and intrinsic cellular regulators for controlling vegetative cell differentiation.”

For More details: https://stemcell-regenerative.conferenceseries.com/
For more details: stemregen@memeetings
what’s app: +44 7723 582425

Comments

Post a Comment

Popular posts from this blog

Utilizing Single Cells To Get the Whole Picture of the Epigenetic

Image
Genes may control what qualities are passed down from parent to posterity, but every cell expresses these genes distinctively dependent on “external” epigenetic modifications.   Epigenetics doesn't adjust the quality arrangement (genotype), however, they do impact cell behavior and function (phenotype). The study of epigenetics helps us see how phenotypic changes lead to malady, stem cell differentiation, and essentially, what drives the fate of every cell in the human body. The epigenome isn't reliable between cells, or even between cells of a similar sort. Individual changes travel every which way all through a cell's lifetime. In this way, researchers are confronted with the precarious test as they attempt to the role of epigenetics in infection and development. Understanding intercellular heterogeneity is key here. The epigenome must be inspected at single-cell resolution. Now with the advancement of single-cell sequencing strategies like the single...
Read more

Could Stem Cells Help Corona virus Disease COVID-19 Patients?

Image
Patients who were dealt with while in a serious condition have been released after recuperation. Stem cells can self-renew or multiply while maintaining the potential to become other sorts of cells. They can become cells of the blood, heart, lungs or other body parts.  Stem cells even have a strong function, advancing the formation of the newest blood vessels, cell proliferation, and differentiation and inhibiting inflammatory response, experts say. Stem cell therapy has been utilized in the treatment of some infectious diseases and complications. For instance, it's been tried in treating H7N9 avian flu and showed good results. Human and animal studies have shown that after infection with coronavirus, the rapid replication of the virus in the body and the subsequent inflammatory response cause damage to alveolar epithelial cells and capillary endothelial cells, causing diffuse interstitial and alveolar edema, and pulmonary function. Impaired, leading to acute hy...
Read more

Why Tissue Engineering and 3D Cell Culture Is a Tactic Not a Strategy

Image
Tissue Engineering is a part of regenerative Medicine, itself a part of the biomedical design. Tissue Engineering and regenerative medication is worried about the substitution or recovery of cells, tissues (the focal point of tissue designers) Tissue Engineering includes the utilization of a tissue framework for the development of new practical tissue for a medicinal reason or organs to reestablish typical natural capacity. Goals of tissue engineering ·          Tissue Engineering is to amass usefully develops that reestablish, keep up, or improve harmed tissues or entire organs. ·          Fake skin and ligament are instances of built tissues that have been affirmed by the FDA. ·          Nonetheless, at present, they have restricted use in human patients. How does tissue engineering and regenerative medicine work? Tissues are the fundamental...
Read more